Semaglutide Ultima
| Weeks |
Weekly dose |
Stage |
Purpose |
| Weight management schedule |
| 1–4 |
0.25 mg |
Starting phase |
Low opening dose to check tolerance |
| 5–8 |
0.5 mg |
Step-up 1 |
First increase in dose |
| 9–12 |
1.0 mg |
Step-up 2 |
Second increase in dose |
| 13–16 |
1.7 mg |
Step-up 3 |
Third increase in dose |
| 17+ |
2.4 mg |
Target dose |
Highest research dose used |
| Blood sugar control schedule |
| 1–4 |
0.25 mg |
Starting phase |
| 5–8 |
0.5 mg |
Maintenance 1 |
| 9–12 |
1.0 mg |
Maintenance 2 |
| 13+ |
2.0 mg |
Highest research dose |
| Key facts |
| How it's given |
Injected under the skin (subcutaneous) once a week |
| Timing |
Any time of day, with or without food |
| Dose increases |
Raise the dose step by step every 4 weeks to reduce side effects |
| Maximum dose |
2.4 mg per week for weight management; 2.0 mg per week for blood sugar control |
| Missed dose |
Take it within 5 days, or skip it and continue the schedule |
| Common side effects |
Nausea (44%), diarrhea (30%), vomiting (24%), constipation (24%) |
| Do not use if |
You or a family member has had thyroid C-cell tumors, or you have MEN2 syndrome |
| For women |
Stop at least 2 months before a planned pregnancy because it stays in the body a long time; a pregnancy test may be needed before starting |
| Disclaimer |
For research and educational reference only, not medical advice |
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