PE-22-28 10mg by Peptide Hubs - Cognitive Enhancement & Neuroplasticity

PE-22-28 is a powerful neuroactive heptapeptide designed to support higher brain function, mental clarity, and long-term neuroplasticity. Developed from the biologically active region of ACTH, PE-22-28 works directly on the central nervous system to improve cognitive performance, learning capacity, and neural resilience without stimulating stress hormones or causing overstimulation.

Unlike stimulant nootropics that push the nervous system into overdrive, PE-22-28 works at the signaling level—enhancing synaptic communication, improving neuron resilience, and supporting balanced neurotransmitter activity. This makes it ideal for individuals who want sharper thinking, improved memory, and sustained mental endurance without crashes or burnout.

PE-22-28 is commonly used by professionals, students, athletes, and biohackers seeking long-term brain optimization rather than short-lived stimulation. It supports mental clarity, focus stability, and information retention, especially under stress or during periods of high cognitive demand.

How PE-22-28 Enhances Brain Performance

PE-22-28 acts on melanocortin pathways involved in neuroprotection and synaptic plasticity. By modulating neural signaling, it enhances communication between neurons while protecting them from oxidative and metabolic stress. This translates into clearer thinking, faster processing speed, and improved learning efficiency.

Unlike harsh stimulants, PE-22-28 does not spike dopamine or adrenaline. Instead, it supports long-term neural adaptability, making it ideal for consistent daily use or extended cognitive cycles. Users often report improved memory recall, sharper focus, reduced mental fatigue, and greater emotional resilience during demanding workloads.

Primary Benefits

• Enhanced focus and mental clarity
• Improved learning speed and information retention
• Neuroprotective support against cognitive stress
• Reduced mental fatigue and burnout
• Improved mood stability and emotional control
• Supports long-term brain health and plasticity

Recommended Use

PE-22-28 is commonly used in low microgram ranges and can be administered daily or in short cycles depending on goals.

Typical cognitive protocol:
• 200-500 mcg daily
• Morning or early afternoon use preferred
• Cycle length: 4-8 weeks with breaks

It pairs well with other cognitive or recovery peptides and does not cause tolerance buildup when used responsibly.

Stacking Recommendations

• Semax - Enhances focus, alertness, and executive function
• Selank - Reduces anxiety and improves emotional balance
• Cerebrolysin - Advanced neuroregeneration support

Comparison Table